导师介绍 | ||
导师姓名 | 甘莉 |
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导师性别 | 女 | |
职务职称 | 副研究员 | |
所在院系 | 化学与环境工程学院 制药工程系 | |
一级学科 | 化学工程与技术 | |
二级学科 | 制药工程 | |
研究方向 | 新型药物传递系统 | |
联系电话 | 13564243471 | |
电子邮箱 | ganli@sit.edu.cn | |
个人简介 | ||
本人主要从事功能性纳米载体的设计及其在眼组织转运和生物效应机理的研究;新型纳米制剂(脂肪乳、脂质体等)的开发及产业化研究。目前,主持或参与了国家973计划、863计划(2007AA021604)、国家自然科学基金(81102387)、上海市科委(11ZR1444700)等多项项目,在Biomaterials、Drug Discovery Today国内外一流学术期刊发表论文30余篇,申请新型专利12项,其中PCT专利1项,获授权专利6项。中科院青年创新促进会会员,中科院上海药物所首届“新星计划 A类”人才,曾获2015年中国产学研合作创新奖 个人奖,2012年中国药学会“第十一届全国青年药学工作者最新科研成果交流会”优秀论文三等奖。国家食品药品监督管理局新药评审专家。 在新制剂的研发和产业化推进方面,完成了H205眼用乳剂、环孢素A眼用乳剂、前列地尔脂肪乳和磷酸奥司他韦胶囊等近10项新制剂的开发,先后协助企业完成了眼用乳剂及注射乳剂等3条生产线的建立。其中环孢素A眼用乳剂获得了新药2类临床批件,临床研究结果显示其治疗效果显著优于对照组。为推进该项目的产业化,已协助上海医药集团有限公司建成了国内首条自动化眼用乳剂(100L/批)生产线,将投入产业化应用。 | ||
学习与工作经历 | ||
1996.09 --- 2000.07 中国药科大学英语药学专业理学士 2000.09 --- 2003.07 中国药科大学药剂学硕士 2006.09 --- 2009.07 中国药科大学药剂学博士 2003.07 --- 2014.06 中科院上海药物研究所药物制剂研究中心 副研究员 硕士生导师 2013.03 --- 2013.12 国家药监局药品审评中心 外聘专家 2014.07 --- 至今 上海应用技术学院 化学与环境工程学院制药工程系 2015.10 --- 2017.01 国家药监局药品审评中心 外聘专家 | ||
科研工作与成果 | ||
承担科研项目 ① 2016上海市科促会“联盟计划”——丁酸氯维地平脂肪乳剂制备工艺研究,负责人 ② 国家自然科学基金——透明质酸修饰的眼用核-壳纳米组装体的设计及对炎症组织靶向性的研究(81102387),负责人 ③ 上海市科委自然科学基金——CD44介导的眼用核-壳纳米组装体的设计及对顽固性葡萄膜炎抑制机理的研究(11ZR1444700),负责人 ④ 国家重大科学研究计划(973计划)——纳米技术改善难溶性药物功效的应用基础研究(2009CB90330),技术骨干 ⑤ 国家高技术研究发展计划(863计划)——眼部上皮多肽给药制剂的研究(2007AA021604),技术骨干 ⑥ 上海市科委登山行动计划——环孢素眼用乳剂的研究(064319006-2),技术骨干 发表论文 1) Yanmei Qin, Yongfeng Tian, Yang Liu, Dong Li, Hua Zhang, Yeqian Yang, Jianping Qi, Hao Wang, Li Gan*. Hyaluronic acid‐modified cationic niosomes for ocular gene delivery: improving transfection efficiency in retinal pigment epithelium. Journal of Pharmacy and Pharmacology, 2018, 70(9): 1139-1151. 2) Yongfeng Tian, Hua Zhang, Yanmei Qin, ,Dong Li, Yang Liu, Hao Wang, Li Gan*. Overcoming drug-resistant lung cancer by paclitaxel-loaded hyaluronic acid-coated liposomes targeted to mitochondria. Drug Development and Industrial Pharmacy, 2018, 44(12): 2071-2082. 3) Dong Li, Jie Zhuang, Yinqian Yang, Dandan Wang, Jinlong Yang, Haisheng He, Wufa Fan, Amrita Banerjee, Yi Lu, Wei Wu, Li Gan*, Jianping Qi. Loss of integrity of doxorubicin liposomes during transcellular transportation evidenced by fluorescence resonance energy transfer effect. Colloids and Surfaces B: Biointerfaces, 2018, 171: 224-232. 4) Li Dong; Zhuang Jie; He Haisheng; Jiang Sifan; Banerjee Amrita; Lu Yi; Wu Wei; Mitragotri Samir; Gan Li*; Qi Jianping. Influence of Particle Geometry on Gastrointestinal Transit and Absorption following Oral Administration. ACS Appl. Mater. & Inter. 2017,9(49): 42492–42502 5) Zhihui Wang, Yongfeng Tian, Hua Zhang, Yanmei Qin, Dong Li, Li Gan*, Fanhong Wu. Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells. Int. J. Nanomed. 2016,6485-6597 6) Li Gan, Jing Wang, Yanan Zhao, Dan Chen, Chunliu Zhu, Jianping Liu, Yong Gan*. Hyaluronan-modified core-shell liponanoparticles targeting CD44-positive retinal pigment epithelium cells via intravitreal injection. Biomaterials 2013,34:5978-5987. 7) Li Gan, Jing Wang, Min Jiang, Hanah Bartlett, Defang Ouyang, Frank Eperjesi, Jianping Liu, Yong Gan*. Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers. Drug Discov. Today 2013,18:290-297. 8) Li Gan, Yiping Gao, Chunliu Zhu, Xinxin Zhang, Yong Gan. Novel pH-sensitive lipid-polymer composite microspheres of 10-hydroxycamptothecin exhibiting colon-specific biodistribution and reduced systemic absorption. J. Pharm. Sci. 2013,102:1752-1759 9) Min Jiang, Li Gan (Co-first author), Chunliu Zhu, Yang Dong, Jianping Liu, Yong Gan*. Cationic core-shell liponanoparticles for ocular gene delivery. Biomaterials 2012,33: 7621-7630. 10) Jinqiu Shen,Li Gan (Co-first author), Chunliu Zhu, Xinxin Zhang, Yang Dong, Min Jiang, Jiabi Zhu, Yong Gan*. Novel NSAIDs ophthalmic formulation: flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect. Int. J. Pharm. 2011,412: 115-122. 11) Li Gan, Shun Han, Jinqiu Shen, Chunliu Zhu, Xinxin Zhang, Yong Gan*. Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: improving preocular retention and ocular bioavailability. Int. J. Pharm. 2010, 396 (1-2): 179-187. 12) Li Gan, Yong Gan*, Chunliu Zhu, Xinxin Zhang, Jiabi Zhu. Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: in vitro and in vivo results. Int. J. Pharm. 2009, 365 (1-2): 143-149. 13) Shun Han, Jinqiu Shen, Yong Gan, Xinxin Zhang, Chunliu Zhu, Li Gan*. Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen: Low irritancy and higher bioavailability. Acta Pharmacol. Sin. 2010, 31: 990-998. 14) Hongzhen Yu, Sifei Han, Ping Li, Chunliu Zhu, Xinxin Zhang, Li Gan, Yong Gan*. An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione. J. Pharm. Sci. 2011,100(11):5048-5058. 15) Yiping Gao, Chunliu Zhu, Xinxin Zhang, Li Gan, Yong Gan*. Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique. J.Microencapsul. 2011,28(6):549-556. 16) Ping Li, Chun-liu Zhu, Xinxin Zhang, Li Gan, Hongzhen Yu, Yong Gan*. Reversible Inhibitory Effects of Saturated and Unsaturated Alkyl Esters on the Carboxylesterases Activity in Rat Intestine.Lipids.2010, 45(7):603-612 17) Ping Li, Hongzhen Yu, Xinxin Zhang, Li Gan, Chunliu Zhu, Yong Gan*. Absorption enhancement of adefovir dipivoxil by incorporating MCT and ethyl oleate complex oil phase in emulsion. Acta Pharmacol. Sin. 2010,31(7):881-888 18) Shiyan Guo, Xinxin Zhang, Li Gan, Chunliu Zhu, Yong Gan*. Effect of PEO-PPO-PEO micelles on pharmacokinetics and intestinal toxicity of CPT-11: Potential Involvement of BCRP (ABCG2). J. Pharm. Pharmacol. 2010.62:973-984 19) Sifei Han, Tingting Yao, Xinxin Zhang, Li Gan, Chunliu Zhu, Hongzhen Yu, Yong Gan*. Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: effects of lipid composition and formulation. Int. J. Pharm. 2009, 379: 18-24 20) Zhen Ge, Xinxin Zhang, Li Gan,Yong Gan*. Redispersible, dry emulsion of lovastatin protects against intestinal metabolism and improves bioavailability. Acta Pharmacol. Sin. 2008, 29: 990-997. 21) Xinxin Zhang, Weisan Pan, Li Gan, Chunliu Zhu, Yong Gan*. Effects of BCRP inhibitors and pharmaceutical excipients on decreasing gastrointestinal toxicity of camptothecin analogues. Acta Pharmacol. Sin. 2008, 29: 1391-1398 22) Xinxin Zhang, Yong Gan, Li Gan, Shufang Nie, Weisan Pan*. PEGylated nanostructured lipid carriers loaded with 10-hydroxycamptothecin: an efficient carrier with enhanced anti-tumour effects against lung cancer. J. Pharm. Pharmacol.2008, 60: 1077-1087 23) Xinxin Zhang, Weisan Pan, Li Gan, Yong Gan*,Shufang Nie. Preparation of a dispersible PEGylate nanostructured lipid carriers (NLC) loaded with 10-hydroxycamptothecin by spay-drying. Chem. Pharm. Bull. 2008, 56: 1645-1650 24) Huijun Xie, Yong Gan*, Suwei Ma, Li Gan. Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network. Drug Dev. Ind. Pharm. 2008, 34: 363-372. 25) 秦艳梅,田永丰,李东,甘莉*. 新生血管型老年性黄斑变性基因治疗非病毒载体研究进展 中国新药与临床杂志 2016,12(35):831-840 26) 李东,童家勇,田永丰,秦艳梅,甘莉*. 国内外营养型脂肪乳剂研究进展 药学进展 2016,40(7):498-504 27) 赵亚男,甘莉,王静,陈熙,贾征,甘勇,刘建平. 透明质酸修饰的核壳纳米粒对视网膜色素上皮细胞基因转染效率的研究 药学学报 2014,49 (5):711-717 28) 王静,甘莉,甘勇,刘建平. 透明质酸修饰的地塞米松核壳纳米粒的制备及表征. 中国药科大学学报 2013,44(2):117-123 29) 蒋敏,甘莉,甘勇,刘建平*.新型眼用脂质载体制剂的研究进展. 中国药科大学学报2012,47(16),1265-1269. 30) 甘莉,危军,甘勇*,Degenhard Marx,李健. 新的疫苗技术——鼻腔疫苗, 中国医药工业杂志. 2010, 41(4), 298-304. 31) 甘莉,甘勇,沈锦秋,朱家壁*. 地塞米松纳米立方液晶眼用制剂家兔房水药代动力学 中国药科大学学报 2009, 40(4), 327-331. | ||
社会学术团体兼职 | ||
中科院青年创新促进会会员,上海药物所首届“新星计划 A类”人才。国家食品药品监督管理局新药评审专家。 | ||
主要研究方向 | ||
(1)功能性纳米载体的设计及其在眼组织转运和生物效应机理的研究; (2)新型纳米制剂(脂肪乳、脂质体等)的开发及产业化研究 | ||
近3年指导研究生的就业情况 | ||
累计指导本校研究生7名,其中3名在读。已毕业研究生(李东)就业于上:闳鹨揭┯邢薰镜却笮椭埔┕。 |